Estimating minimally important differences for the PROMIS pain interference scales: results from 3 randomized clinical trials

Minimally important differences for Patient Reported Outcomes Measurement Information System pain interference for individuals with back pain

BACKGROUND The minimally important difference (MID) refers to the smallest change that is sufficiently meaningful to carry implications for patients' care. MIDs are necessary to guide the interpretation of scores. This study estimated MID for the Patient Reported Outcomes Measurement Information System (PROMIS) pain interference (PI). METHODS Study instruments were administered to 414 people ...

Innovations in Stroke: The Use of PROMIS and NeuroQoL Scales in Clinical Stroke Trials.

Determining minimally important score differences in scales of the Copenhagen Psychosocial Questionnaire.

AIM To determine minimally important differences (MIDs) for scales in the first version of the Copenhagen Psychosocial Questionnaire (COPSOQ). METHODS Data were taken from two separate studies: a national population survey (N = 1062), and an intervention study at 14 workplaces (N = 1505). On the basis of the population survey, the MID for each COPSOQ scale was calculated as one-half of a stan...

Clinical Research Methodology 3: Randomized Controlled Trials.

Randomized assignment of treatment excludes reverse causation and selection bias and, in sufficiently large studies, effectively prevents confounding. Well-implemented blinding prevents measurement bias. Studies that include these protections are called randomized, blinded clinical trials and, when conducted with sufficient numbers of patients, provide the most valid results. Although conceptua...

Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with pain.

This two-phase study was conducted to identify relevant domains of patient-reported outcomes from the perspective of people who experience chronic pain. In Phase 1, focus groups were conducted to generate a pool of patient outcome-related domains and their components. The results of the focus groups identified 19 aspects of their lives that were significantly impacted by the presence of their s...